The Saltok System was a star system along the Cardassian-Federation border.

In 2369 Captain Gedna Tachion, in command of the USS Cairo, managed to bluff three Cardassian light cruisers into retreating from the system.

By 2370, a Federation colony had been established on Saltok IV, and when the Demilitarized Zone was established that year, the Saltok System was placed within it. (DS9 episode: The Maquis, Part I)

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