On stardate 50893.6 a Borg cube was detected entering the Typhon Sector. The Comanche, due to its four nacelles allowing it to maintain high warp speeds for long periods of time, was assigned to pace the cube at a safe distance. When it began destroying the colony of Ivor Prime, her commander disobeyed orders and made a high warp run at the planet, managing to beam 537 colonists aboard using personnel, emergency, and cargo transporters. ("First Contact")
The Comanche would later serve in the Sixth Fleet during the Dominion War.