The USS Hippolyle was a Mediterranean class destroyer that served in the Sixth Fleet during the Dominion War.
In 2373 the vessel was transferred from the Second Fleet to the Sixth Fleet's 141st Task Force. She served in Beta Squadron.
During Operation Return the Hippolyle led a five starship unit in a flanking maneuver that resulted in the destruction of Jem'Hadar carrier and two Hideki class heavy scouts. ("Operation Return")
After the war, she was transferred to the Tholian border.