The USS Seminole was a Cheyenne class cruiser serving in Starfleet during the 24th century.
In early 2371 the Seminole transported Commander Benjamin Sisko to Earth to brief Starfleet Security on the Dominion Threat. ("New Orders")
The ship was part of the Seventh Fleet during the Dominion War and was destroyed during the Battle of Tyra.
A single escape pod survived the cruiser's destruction, and its five occupants were imprisoned on Hekiss. ("Familiar Faces")