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The USS Thalestis was a Mediterranean class destroyer serving in Starfleet during the 24th century.

Ann Portikos was assigned to the ship as a shuttle pilot after she graduated from Starfleet Academy.

In 2371 she was assigned to the BeTau Sector.

That same year information on her assignments, armaments and personnel were leaked to the Tal Shiar by Harelian agents.   ("Shakedown Cruise")

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