The vessel was part of a joint Starfleet-Vulcan operation to combat Orion Syndicate arms smuggling operations to the Vulcan Isolation Movement in 2365 under the command of Robert Leyton.
The frigate transported a team to Starbase 12 to assess the crew of the USS Bozeman following their reemergence from nine decades in a temporal causality loop.
On stardate 47943.2, the Thomas Paine, underwent an engine upgrade at Starbase 92. During the upgrades, Lieutenant Ferrel of the Engineering Department transferred to the USS Enterprise-D.
The next year the frigate arrived at the Antares Fleet Yards for a two years of refitting and upgrading.
By 2375 Stefan Bartok was the vessel's XO when it was relaunched. The ship immediately joined the Sixth Fleet.